9 Differences between Inotropic, Chronotropic and Dromotropic (With Table)

There are many drugs for the heart that are used to treat different heart diseases. People with heart diseases need to know how these drugs work and what side effects they might have.

There are many different kinds of cardiac drugs, such as inotropic, chronotropic, diuretics, anti-thrombotic, dromotropic, and so on. These medicines are very important for the health of your heart.

Don’t try to treat your heart condition with over-the-counter drugs. We suggest getting help from a doctor who can give you a diagnosis and a prescription.

So, what’s the main difference between inotropic, chronotropic, and dromotropic?

Inotropes are drugs for the heart that affect how it contracts. Chronotropic is a drug for the heart that affects how fast it beats, and dromotropic is a drug for the heart that affects how it sends signals.

These heart medications are very important for keeping the heart healthy. This article goes into detail about how inotropic, chronotropic, and dromotropic are different. Read on to find out what they mean and how they might make you feel.

Comparison Table (Inotropic vs. Chronotropic vs. Dromotropic)

Inotropic

Chronotropic

Dromotropic

These are heart medicines that change how the heart beats.

These are heart medicines that change the rate of the heart.

These are heart medicines that affect the parts of the heart that make it work.

Positive and negative inotropic drugs are the two types of heart drugs.

There are two types of heart drugs: those that are positive and those that are negative.

Positive dromotropic drugs and negative dromotropic drugs are the two types of heart drugs.

The cardiac drug makes the heart beat.

The heart rate is controlled by the drug.

The cardiac drug controls the parts of the heart that make it work.

The positive inotropic drug makes the heart beat faster and harder.

The negative inotropic drug makes it harder for the heart to relax.

The heart rate goes up when you take a positive chronotropic.

The heart rate slows down because of the negative chronotropic drug.

A positive dopaminergic drug speeds up the way the AV nodes work.

The AV nodal conduction is slowed down by the negative dromotropic drug.

Both the systolic and diastolic functions of the heart are affected by the inotropic drug.

The chronotropic drug changes the way the heart and nerves send and receive electricity.

The AV nodal conduction is changed by the dromotropic medication.

The word “inotropic” comes from the Greek word “ino,” which means “fibre” or “tendon.”

Chronotropic comes from the Greek words for time, “chrono,” and “tropos,” which means “a turn.”

The word “dromotropic” comes from the Greek word “dromo,” which means “to run” or “to race.”

Examples:

Adrenaline and dopamine are good inotropic drugs.

The drugs propanolol and labetalol are inotropic negative-action drugs.

Examples:

Adrenaline is a good chronotropic drug.

Digoxin is a bad chronotropic drug.

Examples:

Phenytoin is a good dopaminergic drug.

Negative dromotropic drug: verapamil

What Exactly Is an Inotropic Drug?

It is a type of heart medicine that controls how the heart muscles squeeze. Most of the time, these heart medications affect the way the heart beats in two ways.

The positive inotropic drug is a heart drug that makes the heart contract more. The negative inotropic drugs make it harder for the heart to beat.

Science says that inotropes are medicines that help the heart contract. Heart attacks and strokes can also be treated with these drugs.

Positive and negative inotropes are the two types of inotropes. How well these heart medications work depends on how sick the patient is.

Dopamine and adrenaline are both good examples of inotropic drugs. Labetalol and propranolol are two examples of drugs that make the heart beat slower.

What is a chronotropic drug?

It is a type of heart medicine that helps keep the heart rate in check. The sodium, potassium, and calcium channels in the heart are controlled by these medicines.

These heart medicines let more or less ions flow into the cells that make the heart beat. Positive and negative chronotropes are the two types of chronotropic drugs.

The heart rate goes up when the positive chronotropes are present. The heart rate slows down because of the negative chronotropes. Science says that these heart medications change the rate and rhythm of the heart.

Adrenaline is a good example of a positive chronotrope, and digoxin is a bad example of a negative chronotrope. Remember that a professional medical doctor has given you these heart medicines.

What Exactly Is A Dromotropic Drug?

It is a type of medicine for the heart that changes how the heart’s conducting tissue works. The cardiac drug improves the way people’s hearts beat.

Science says that dromotropes change the speed of travel from the SA node to the AV node. People know that the AV node is where tissues connect.

Positive and negative dromotropes are the two types of dromotropes. The positive dromotropic drug speeds up the movement of conducting tissue, while the negative dromotropic drug slows it down.

Phenytoin is an example of a positive dromotrope, and verapamil is an example of a negative dromotrope. Depending on the patient’s condition, these heart medications are given to them.

Differences between Inotropic, Chronotropic, and Dromotropic

  1. Inotropes are drugs for the heart that affect how it contracts. Chronotropic is a drug for the heart that changes the rate of the heart. Dromotropic is another drug for the heart that changes the way the heart’s conducting tissues work.
  2. Positive drugs and negative drugs are the two types of inotropic drugs. Chronotropic drugs are either good for you or bad for you. There are both good and bad drugs in the dopaminergic category.
  3. Inotropic cardiac drugs are known to change the force that makes the heart muscle contract. Chronotropic cardiac drugs help control the heart rate of a patient.
  4. Most of the time, dromotropic cardiac drugs are used to change how the heart’s conducting tissues work.
  5. Beta-blockers or dopamine are examples of inotropic drugs, and atropine or metoprolol are examples of chronotropic drugs for the heart. Phenytoin and verapamil are both types of dopaminergic drugs.

Similarities between Inotropic, Chronotropic, and Dromotropic

  1. Both will last for a long time.
  2. Both are about how the heart works.
  3. Both come from the Greek language.
  4. Both have negative and positive forms.

Frequently Asked Questions

  • What are inotropic effects?

Inotropes are substances that change the energy or force with which muscles contract. The positive inotropic effect makes muscle contractions stronger, while the negative inotropic effect makes muscle contractions less strong.

  • Is digoxin chronotropic or inotropic?

Positive inotropic digitalis glycosides make the heart muscle contract more, while negative chronotropic digitalis glycosides slow the heart rate.

  • Are beta-blockers inotropic or chronotropic?

Antianginal effects have negative effects on both inotrophy and chronotropy. Because of these two effects, the heart has to work less and needs less oxygen.

So, the bad effect of chronotropic makes the life-saving property of controlling the heart rate even better.

Beta-blockers are easy to adjust for the best rate control in many diseases.

  • Is dopamine inotropic, chronotropic, or domotropic?

Stimulated beta1-adrenergic receptors in the heart cause positive inotropy, which makes muscles contract more; positive chronotropy, which makes the heart beat faster; and positive dromotropy, which makes the rate of conduction through the AV node go faster.

Conclusion

Some of the most important differences between inotropic, chronotropic, and dromotropic have been discussed above and in the podcast video.

The article also talks about the different kinds of medications and gives examples of each kind. I hope that the article helped. Feel free to share your thoughts or experiences in the space below. Best of luck

Additional Resources and References

  1. Osowski U. Congestive Heart Failure. National Institute of Health
  2. E. N. Moore. Effect of Inotropic, Chronotropic, and Dromotropic. Wiley Online Library
  3. Reginald P. Sequeira. Dromotropic. Science Direct
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